The Detailed Information of Protein
| Protein ID: | ICDB_Pro_1702 |
|---|---|
| Protein Name: | Inositol 1;4;5-triphosphate receptor associated 1 |
| Function: | Plays a role as NO/PRKG1-dependent regulator of IP3-induced calcium release; its phosphorylation by PRKG1 inhibits bradykinin and IP3-induced calcium release from intracellular stores. Recruits PRKG1 to the endoplasmic reticulum and may mediate the assembly of PRKG1 and ITPR1 in a macrocomplex. Involved in PRKG1 signaling cascade leading to inhibition of platelet activation and aggregation. Mediates also NO-dependent inhibition of calcium signaling in gastrointestinal smooth muscle contributing to NO-dependent relaxation. |
| Sequence: | MGRSLTCPFGISPACGAQASWSIFGVGTAEVPGTHSHSNQAAAMPHIPEDEEPPGEPQAAQTQDSPSAGPFPSPPTIVLTGDASSPEGETDKNLVNRAPSPHRRLSHRHLKVSTASLTSVDPSGHVIDLVNDQLPDISISEEDKKKNLALLEEAKLVSERFLTRRGRKSRSSLGDSPSAVSPNLSSGASPASSRSCSLTISTSPGLDICSGPQSPLPGAPPQQKGHEDGVSSPCPGEPNVSKGLADLKQNDQRKVSQGRLAPRSPTVEKTKELTVEQKENFDPLQHVEATPMAQASGASISGKMALNSPQPGPAEMELGRQLLKTAREGNPLPRTTAQGSGGTVSPHSLGQGSAGEPMGPKAGSKAELRSPVSRPPLIRGVSWDSSPEEPGPLLQKVLAKLPLAEEEKRFPGKAKPAKPPGLKDFQIQVQPVRMQKLTKLREEHILMRNQNLVGFKLPELSEAAEQDKGVSPELAPAAEEEESKSGLDVMPNISDILLRKLRVHKSLTGSAPPLTEKEVENVFVQLSLAFRNDSYTLESRINQAERERNLTEENTEKELENFKASITSSANIWYHCEHRETYQKLLEDIAVLHRLAARLSSRAEVVGAVRQEKRMSKATEVMMQYVENLKRTYEKDHAELMEFKKLANQNSSRSCGPSEDGVPRTARSMSLTMGKNMPRRRVSVAVVPKFNALNLPGQAPSSSPMPSLPALSESSNGKSSISVSPALPALLENGKTNAEANCEVGAPVPLPSCLEETSQETKAKAEEEAYSKGYQEGVKKTEELQDLKEEEEEEQKTESPEEPEEVEETQEDEKDQGSSKLEELVHFLQVMYPKLCQHWQVIWMMAAVMLVLSVVLGLYSSYNSCTEEADGPPGRSTCSAAQRDSWWSSGLQQELPAEQ |
| Gene Name: | Irag1; Irag; Mrvi1 |
| Organism: | Mus musculus (Mouse) |
| Length: | 899 | PDB: |
| Ligand Binding: |
1. DICL_CP
2. DICL_Pep
|
| AlphaFoldDB: | AF-Q9WUX5-F1-model_v4.pdb |
| Binding site: | |
| Disease: | |
| Location: | Highly expressed in smooth muscle such as aorta; colon and uterus. Detected in the brain; in the thalamus; in the hippocampus and myenteric plexus. Highly expressed in megakaryocytes. Highly expressed in megakaryocytes. Highly expressed in megakaryocytes. Down-regulated during macrophage differentiation |
| DOI ID: | 10.1038/sj.onc.1202419; 10.1126/science.1112014; 10.1371/journal.pbio.1000112; 10.1038/sj.emboj.7600440; 10.1016/j.febslet.2004.08.030; 10.1182/blood-2005-10-026294; 10.1016/j.cell.2010.12.001 |
| RefSeq: | XP_006507478.1 [Q9WUX5-2]; XP_006507479.1 [Q9WUX5-2] |